Fast and accurate joint inference of coancestry parameters for populations and/or individuals.

ABSTRACT: We introduce a fast, new algorithm for inferring from allele count data the FST parameters describing genetic distances among a set of populations and/or unrelated diploid individuals, and a tree with branch lengths corresponding to FST values. The tree can reflect historical processes of splitting and divergence, but seeks to represent the actual genetic variance as accurately as possible with a tree structure. We generalise two major approaches to defining FST, via correlations and mismatch probabilities of sampled allele pairs, which measure shared and non-shared components of genetic variance. A diploid individual can be treated as a population of two gametes, which allows inference of coancestry coefficients for individuals as well as for populations, or a combination of the two. A si

SUBMITTER: Mary-Huard T 

PROVIDER: S-EPMC9888729 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature