The lung, the niche, and the microbe: Exploring the lung microbiome in cancer and immunity.

ABSTRACT: The lung is a complex and unique organ system whose biology is strongly influenced by environmental exposure, oxygen abundance, connection to extrapulmonary systems via a dense capillary network, and an array of immune cells that reside in the tissue at steady state. The lung also harbors a low biomass community of commensal microorganisms that are dynamic during both health and disease with the capacity to modulate regulatory immune responses during diseases such as cancer. Lung cancer is the third most common cancer worldwide with the highest mortality rate amongst cancers due to the difficulty of an early diagnosis. This review discusses the current body of work addressing the interactions between the lung microbiota and the immune system, and how these two components of the pulm

SUBMITTER: Huynh M 

PROVIDER: S-EPMC9888758 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature