Parahydrogen-Induced Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation.

ABSTRACT: The feasibility of Carbon-13 Radiofrequency (RF) Amplification by Stimulated Emission of Radiation (C-13 RASER) is demonstrated on a bolus of liquid hyperpolarized ethyl [1-¹³ C]acetate. Hyperpolarized ethyl [1-¹³ C]acetate was prepared via pairwise addition of parahydrogen to vinyl [1-¹³ C]acetate and polarization transfer from nascent parahydrogen-derived protons to the carbon-13 nucleus via magnetic field cycling yielding C-13 nuclear spin polarization of approximately 6 %. RASER signals were detected from samples with concentration ranging from 0.12 to 1 M concentration using a non-cryogenic 1.4T NMR spectrometer equipped with a radio-frequency detection coil with a quality factor (Q) of 32 without any modifications. C-13 RASER signals were observed for

SUBMITTER: Nelson C 

PROVIDER: S-EPMC9889133 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature