White matter lesion load determines exercise-induced dopaminergic plasticity and working memory gains in aging.

ABSTRACT: Age-related dopamine reductions have been suggested to contribute to maladaptive working memory (WM) function in older ages. One promising intervention approach is to increase physical activity, as this has been associated with plasticity of the striatal dopamine system and WM improvements, however with individual differences in efficacy. The present work focused on the impact of individual differences in white-matter lesion burden upon dopamine D2-like receptor (DRD2) availability and WM changes in response to a 6 months physical activity intervention. While the intervention altered striatal DRD2 availability and WM performance in individuals with no or only mild lesions (p < 0.05), no such effects were found in individuals with moderate-to-severe lesion severity (p > 0.05). Follow-up ana

SUBMITTER: von Cederwald BF 

PROVIDER: S-EPMC9889313 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature