PPAR-γ alleviates the inflammatory response in TNF-α-induced fibroblast-like synoviocytes by binding to p53 in rheumatoid arthritis.

ABSTRACT: Rheumatoid arthritis (RA) is characterized by synovial inflammation, synoviocyte expansion and damage to cartilage and bone. We recently reported that peroxisome proliferator-activated receptor (PPAR)-γ inhibited the proliferation and activation of fibroblast-like synoviocytes (FLS), and was downregulated in RA synovial. In this study we investigated the role of PPAR-γ in RA and the underlying mechanisms. Adjuvant-induced arthritis (AIA) was induced in rats; from D15, AIA rats were orally administered pioglitazone (30 mg·kg^-1·d^-1) or rosiglitazone (4 mg·kg^-1·d^-1) for 14 days. Collagen-induced arthritis (CIA) was induced in wild-type and Ppar-γ^+/- mice. We showed that the expression of PPAR-γ was significantly reduced, whereas that of T

SUBMITTER: Li XF 

PROVIDER: S-EPMC9889328 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature