Proteome analysis of monocytes implicates altered mitochondrial biology in adults reporting adverse childhood experiences.

ABSTRACT: The experience of adversity in childhood has been associated with poor health outcomes in adulthood. In search of the biological mechanisms underlying these effects, research so far focused on alterations of DNA methylation or shifts in transcriptomic profiles. The level of protein, however, has been largely neglected. We utilized mass spectrometry to investigate the proteome of CD14⁺ monocytes in healthy adults reporting childhood adversity and a control group before and after psychosocial stress exposure. Particular proteins involved in (i) immune processes, such as neutrophil-related proteins, (ii) protein metabolism, or (iii) proteins related to mitochondrial biology, such as those involved in energy production processes, were upregulated in participants reporting exposure t

SUBMITTER: Zang JCS 

PROVIDER: S-EPMC9889346 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature