Growth hormone-releasing hormone agonist attenuates vascular calcification in diabetic db/db mice.

ABSTRACT:

Introduction

Vascular calcification (VC) is an independent risk factor for cardiovascular diseases. VC increases mortality of all-causes. VC is one of most common cardiovascular complications in type II diabetes. So far, no therapy has been proven to be effective in treatment of clinical VC. The present study investigated the therapeutic effects of MR409, an agonistic analog of growth hormone-releasing hormone (GHRH-A), on VC in diabetic db/db mice.

Method and result

Diabetic mice were injected with MR409 subcutaneously every day for 8 weeks. Long-term treatment with MR409 improved serum lipid profile and endothelium-dependent relaxation to acetylcholine, and reduced vascular structural injury in diabetic mice without affecting serum growth hormone level. Echocardiography sh

SUBMITTER: Ren HL 

PROVIDER: S-EPMC9889365 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature