Risk of cancer in individuals with Lynch-like syndrome and their families: a systematic review.

ABSTRACT:

Background

Lynch-like syndrome (LLS) tumors have similar clinicopathological features to Lynch syndrome (LS) tumors but have no identifiable pathogenic germline mismatch repair gene variant. However, cancer risks in LLS patients and first-degree relatives (FDRs) are not well defined.

Methods

To clarify LLS-associated cancer risks, a systematic review of all studies examining all cancer risks in LLS was performed. Searching of Medline, Embase, Pubmed, Cochrane and CINAHL databases and reference/citation checking identified relevant studies published between January 1, 1980 and February 11, 2021. Joanna Briggs Institute Appraisal Tools assessed the risk of bias.

Results

Six studies (five cohort/one cross-sectional) were eligible for study inclusion. One study found no d

SUBMITTER: Nugroho PP 

PROVIDER: S-EPMC9889410 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature