A re-appraisal of mesenchymal-epithelial transition (MET) in endometrial epithelial remodeling.

ABSTRACT: Mesenchymal-epithelial transition (MET) is a mechanism of endometrial epithelial regeneration. It is also implicated in adenocarcinoma and endometriosis. Little is known about this process in normal uterine physiology. Previously, using pregnancy and menses-like mouse models, MET occurred only as an epithelial damage/repair mechanism. Here, we hypothesized that MET also occurs in other physiological endometrial remodeling events, outside of damage/repair, such as during the estrous cycle and adenogenesis (gland development). To investigate this, Amhr2-Cre-YFP/GFP mesenchyme-specific reporter mice were used to track the fate of mesenchymal-derived (MD) cells. Using EpCAM (epithelial marker), EpCAM⁺YFP⁺ MD-epithelial cells were identified in all stages of the estrous cy

SUBMITTER: Spooner-Harris M 

PROVIDER: S-EPMC9889438 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature