The effects of the recurrent social isolation stress on fear extinction and dopamine D₂ receptors in the amygdala and the hippocampus.

ABSTRACT:

Background

The present study assessed the influence of recurrent social isolation stress on the aversive memory extinction and dopamine D₂ receptors (D₂R) expression in the amygdala and the hippocampus subnuclei. We also analyzed the expression of epigenetic factors potentially associated with fear extinction: miRNA-128 and miRNA-142 in the amygdala.

Methods

Male adult fear-conditioned rats had three episodes of 48 h social isolation stress before each fear extinction session in weeks intervals. Ninety minutes after the last extinction session, the D₂R expression in the nuclei of the amygdala and the hippocampus (immunocytochemical technique), and mRNA levels for D₂R in the amygdala were assessed (PCR). Moreover, we evaluated the l

SUBMITTER: Wislowska-Stanek A 

PROVIDER: S-EPMC9889440 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature