Intranasal ondansetron microemulsion counteracting the adverse effects of cisplatin: animal study.

ABSTRACT:

Background

Cisplatin is considered one of the most effective and commonly used chemotherapeutic drugs, but despite its high therapeutic effectiveness, most patients treated with cisplatin suffer from nausea and vomiting, neurotoxic side effects, and cerebral psychiatric disorders such as depression. Therefore, the aim of the current work was to explore whether a selective 5-HT₃ receptor antagonist (Ondansetron) administered via the oral route or intranasally in microemulsion form would alleviate cisplatin's adverse effects.

Methods

The selected ondansetron microemulsion was characterized in vitro for particle size, polydispersity, zeta potential, morphology, and nasal permeation, and in vivo in terms of anti-emetic and antidepressant activity, with the assessment

SUBMITTER: Mansour M 

PROVIDER: S-EPMC9889460 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature