Evaluation of the 5-HT_2C receptor drugs RO 60-0175, WAY 161503 and mirtazepine in a preclinical model of comorbidity of depression and cocaine addiction.

ABSTRACT:

Background

Epidemiological data indicate a high rate of comorbidity of depression and cocaine use disorder (CUD). The role of serotonin 2C (5-HT_2C) receptors in the mechanisms responsible for the coexistence of depression and CUD was not investigated.

Methods

We combined bilateral olfactory bulbectomy (OBX), an animal model of depression, with intravenous cocaine self-administration and extinction/reinstatement in male rats to investigate two 5-HT_2C receptor agonists (Ro 60-0175 (RO) and WAY 161503 (WAY)) and the 5-HT_2C-receptor preferring antagonist mirtazapine (MIR; an antidepressant), with the goal of determining whether these drugs alter cocaine-induced reinforcement and seeking behaviors. Additionally, neurochemical analyses were perform

SUBMITTER: Jastrzebska J 

PROVIDER: S-EPMC9889480 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature