Low bone mineral density is a prognostic factor for elderly patients with HCC undergoing TACE: results from a multicenter study.

ABSTRACT:

Objectives

Low bone mineral density (BMD) was recently identified as a novel risk factor for patients with hepatocellular carcinoma (HCC). In this multicenter study, we aimed to validate the role of BMD as a prognostic factor for patients with HCC undergoing transarterial chemoembolization (TACE).

Methods

This retrospective multicenter trial included 908 treatment-naïve patients with HCC who were undergoing TACE as a first-line treatment, at six tertiary care centers, between 2010 and 2020. BMD was assessed by measuring the mean Hounsfield units (HUs) in the midvertebral core of the 11^th thoracic vertebra, on contrast-enhanced computer tomography performed before treatment. We assessed the influence of BMD on median overall survival (OS) and performed multivariate

SUBMITTER: Muller L 

PROVIDER: S-EPMC9889510 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature