Development and external validation of a radiomics model for assessment of HER2 positivity in men and women presenting with gastric cancer.

ABSTRACT:

Background

To develop and externally validate a conventional CT-based radiomics model for identifying HER2-positive status in gastric cancer (GC).

Methods

950 GC patients who underwent pretreatment CT were retrospectively enrolled and assigned into a training cohort (n = 388, conventional CT), an internal validation cohort (n = 325, conventional CT) and an external validation cohort (n = 237, dual-energy CT, DECT). Radiomics features were extracted from venous phase images to construct the "Radscore". On the basis of univariate and multivariate analyses, a conventional CT-based radiomics model was built in the training cohort, combining significant clinical-laboratory characteristics and Radscore. The model was assessed and validated regarding its diagnostic effectiveness an

SUBMITTER: Zhao H 

PROVIDER: S-EPMC9889592 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature