Methodological considerations on segmenting rhabdomyosarcoma with diffusion-weighted imaging-What can we do better?

ABSTRACT:

Purpose

Diffusion-weighted MRI is a promising technique to monitor response to treatment in pediatric rhabdomyosarcoma. However, its validation in clinical practice remains challenging. This study aims to investigate how the tumor segmentation strategy can affect the apparent diffusion coefficient (ADC) measured in pediatric rhabdomyosarcoma.

Materials and methods

A literature review was performed in PubMed using search terms relating to MRI and sarcomas to identify commonly applied segmentation strategies. Seventy-six articles were included, and their presented segmentation methods were evaluated. Commonly reported segmentation strategies were then evaluated on diffusion-weighted imaging of five pediatric rhabdomyosarcoma patients to assess their impact on ADC.

Results</

SUBMITTER: Chatziantoniou C 

PROVIDER: S-EPMC9889596 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature