Protein microarray allergen profiling in bronchoalveolar lavage fluid and serum of horses with asthma.

ABSTRACT:

Background

The diagnostic value of allergen-specific immunoglobulin E (IgE) in horses with asthma is uncertain. A recently developed protein microarray detected abnormally high latex-specific IgE concentrations in the serum of horses with severe asthma.

Objectives

The main objective was to characterize the IgE profiles of asthmatic horses in Switzerland using a protein microarray platform in serum and bronchoalveolar lavage fluid (BALF). The secondary objective was to determine whether serological and BALF allergen-specific IgE concentrations correlated.

Animals

Forty-four asthmatic and 39 control horses ≥5 years of age.

Methods

This prospective cross-sectional study investigated the sensitization profiles of horses with asthma compared with environmentally mat

SUBMITTER: Wyler M 

PROVIDER: S-EPMC9889601 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature