Short-term intra-individual variation of urinary biomarkers in dogs with stable chronic kidney disease.

ABSTRACT:

Background

Active-ongoing kidney damage is present in animals with stable chronic kidney disease (CKD), as reflected by biomarkers in urine. Interpretation of serial messurements of biomarkers requires knowledge of its intra-individual variation.

Aims

To evaluate the short-term intra-individual variation of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 (uNGAL, uKIM-1, respectively) in dogs with stable CKD, and to determine whether normalization to urinary creatinine (uCr) decreases variation.

Animals

Twenty-five dogs with naturally-occurring stable CKD.

Methods

Prospective, observational study. Dogs were diagnosed with CKD based on the International Renal Interest Society guidelines. Dogs were included only if the variation in

SUBMITTER: Chen H 

PROVIDER: S-EPMC9889610 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature