Immune infiltration analysis reveals immune cell signatures in salivary gland tissue of primary Sjogren's syndrome.

ABSTRACT:

Introduction

Mouse models are the basis for primary Sjögren's syndrome (pSS) research. However, the depth of comparisons between mice and humans in salivary gland (SG) immune cells remains limited.

Methods

The gene expression profiles of SGs from normal subjects and pSS patients were downloaded from the Gene Expression Comprehensive Database. The proportion of infiltrating immune cell subsets was then assessed by cell type identification by estimating relative subsets of RNA transcripts (CIBERSORT). An experimental Sjögren's syndrome (ESS) mouse model was successfully constructed using SG protein. Based on mouse SG tissue RNA-Seq data, the seq-ImmuCC model was used to quantitatively analyze the compositional ratios of 10 immune cells in pSS patients and mouse model SG tissue

SUBMITTER: Gong H 

PROVIDER: S-EPMC9889644 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature