Sensitivity of canine hematological cancers to BH3 mimetics.

ABSTRACT:

Background

Inhibition of antiapoptotic B-cell lymphoma 2 (BCL2) proteins by small molecule Bcl-2 homology 3 (BH3) mimetics causes rapid induction of apoptosis of human hematological cancers in vitro and in vivo.

Objectives

Assess in vitro sensitivity of non-neoplastic lymphocytes and primary hematological cancer cells from dogs to venetoclax (VEN) or the dual BCL2/ B-cell lymphoma-extra-large (BCLxL) inhibitor, navitoclax (NAV), and evaluate the association between BCL2 protein expression and VEN sensitivity.

Animals

Nine client-owned dogs without cancer and 18 client-owned dogs with hematological cancer.

Methods

Prospective, nonrandomized noncontrolled study. Lymphocytes isolated from peripheral blood, lymph node, or bone marrow from dogs were incubated with B

SUBMITTER: Jegatheeson S 

PROVIDER: S-EPMC9889650 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature