Reference intervals for plasma, urinary, and salivary concentrations of free metanephrines in dogs: Relevance to the diagnosis of pheochromocytoma.

ABSTRACT:

Background

Measurement of free metanephrines is recommended for screening of pheochromocytoma (PCC) but requires appropriate reference intervals (RIs).

Hypothesis/objectives

To report RIs for plasma, urinary and salivary concentrations of free metanephrines and to determine the diagnostic performance of plasma free normetanephrine (pNMN) and metanephrine (pMN) concentrations in dogs with PCC, hypercortisolism (HC), and nonadrenal illness (NAI).

Animals

Eighty healthy dogs, 11 PCC dogs, 25 HC dogs, 6 NAI dogs.

Methods

Plasma, urine, and saliva were collected prospectively from healthy dogs, and free metanephrine concentrations were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). In addition, medical records of dogs that had plasma free m

SUBMITTER: van den Berg MF 

PROVIDER: S-EPMC9889674 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature