TRPM8 thermosensation in poikilotherms mediates both skin colour and locomotor performance responses to cold temperature.

ABSTRACT: Thermoregulation is a homeostatic process to maintain an organism's internal temperature within a physiological range compatible with life. In poikilotherms, body temperature fluctuates with that of the environment, with both physiological and behavioral responses employed to modify body temperature. Changing skin colour/reflectance and locomotor activity are both well-recognized temperature regulatory mechanisms, but little is known of the participating thermosensor/s. We find that Xenopus laevis tadpoles put in the cold exhibit a temperature-dependent, systemic, and rapid melanosome aggregation in melanophores, which lightens the skin. Cooling also induces a reduction in the locomotor performance. To identify the cold-sensor, we focus on transient receptor potential (trp) channel genes f

SUBMITTER: Malik HR 

PROVIDER: S-EPMC9889708 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature