Immune-based combination therapy to convert immunologically cold tumors into hot tumors: an update and new insights.

ABSTRACT: As a breakthrough strategy for cancer treatment, immunotherapy mainly consists of immune checkpoint inhibitors (ICIs) and other immunomodulatory drugs that provide a durable protective antitumor response by stimulating the immune system to fight cancer. However, due to the low response rate and unique toxicity profiles of immunotherapy, the strategies of combining immunotherapy with other therapies have attracted enormous attention. These combinations are designed to exert potent antitumor effects by regulating different processes in the cancer-immunity cycle. To date, immune-based combination therapy has achieved encouraging results in numerous clinical trials and has received Food and Drug Administration (FDA) approval for certain cancers with more studies underway. This review summarize

SUBMITTER: Ni JJ 

PROVIDER: S-EPMC9889774 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature