Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy.

ABSTRACT: Heart aging is characterized by left ventricular hypertrophy and diastolic dysfunction, which in turn induces a variety of cardiovascular diseases. There is still no therapeutic drug to ameliorate cardiac abnormities in heart aging. In this study we investigated the protective effects of berberine (BBR) and its derivative tetrahydroberberrubine (THBru) against heart aging process. Heart aging was induced in mice by injection of D-galactose (D-gal, 120 mg · kg^-1 · d^-1, sc.) for 12 weeks. Meanwhile the mice were orally treated with berberine (50 mg · kg^-1 · d^-1) or THBru (25, 50 mg · kg^-1 · d^-1) for 12 weeks. We showed that BBR and THBru treatment significantly mitigated diastolic dysfunction and cardiac remodeling in D-gal-in

SUBMITTER: Wang L 

PROVIDER: S-EPMC9889783 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature