Epidemiological and genomic characteristics of global mcr-positive Escherichia coli isolates.

ABSTRACT:

Objective

The worldwide dissemination of colistin-resistant Escherichia coli (E. coli) endangers public health. This study aimed to better understand the global genomic epidemiology of E. coli isolates carrying mobilized colistin resistance (mcr) genes, providing information to assist in infection and prevention.

Methods

Escherichia coli genomes were downloaded from NCBI, and mcr was detected using BLASTP. Per software was used to extract information on hosts, resources, collection data, and countries of origin from GenBank. Sequence types (STs), prevalence of plasmids, antimicrobial resistance genes (ARG), and virulence factors (VF) in these genomes were analyzed. Statistical analyses were performed to assess the relationships betwe

SUBMITTER: Shi J 

PROVIDER: S-EPMC9889832 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature