Prospective and retrospective values integrated in frontal cortex drive predictive choice.

ABSTRACT: To make a deliberate action in a volatile environment, the brain must frequently reassess the value of each action (action-value). Choice can be initially made from the experience of trial-and-errors, but once the dynamics of the environment is learned, the choice can be made from the knowledge of the environment. The action-values constructed from the experience (retrospective value) and the ones from the knowledge (prospective value) were identified in various regions of the brain. However, how and which neural circuit integrates these values and executes the chosen action remains unknown. Combining reinforcement learning and two-photon calcium imaging, we found that the preparatory activity of neurons in a part of the frontal cortex, the anterior-lateral motor (ALM) area, initially enco

SUBMITTER: Hamaguchi K 

PROVIDER: S-EPMC9889848 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature