Five genes as diagnostic biomarkers of dermatomyositis and their correlation with immune cell infiltration.

ABSTRACT:

Background

Dermatomyositis (DM) is a rare autoimmune disease characterized by severe muscle dysfunction, and the immune response of the muscles plays an important role in the development of DM. Currently, the diagnosis of DM relies on symptoms, physical examination, and biopsy techniques. Therefore, we used machine learning algorithm to screen key genes, and constructed and verified a diagnostic model composed of 5 key genes. In terms of immunity, The relationship between 5 genes and immune cell infiltration in muscle samples was analyzed. These diagnostic and immune-cell-related genes may contribute to the diagnosis and treatment of DM.

Methods

GSE5370 and GSE128470 datasets were utilised from the Gene Expression Omnibus database as DM test sets. And we also used R software

SUBMITTER: Zhao X 

PROVIDER: S-EPMC9889851 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature