Plasminogen Activator Inhibitor-1: Potential Inflammatory Marker in Late-life Depression.

ABSTRACT:

Objective

Although several previous studies have examined the association between late-life depression and blood adipokine levels, a marker of chronic inflammation, no studies have comprehensively considered the effects of metabolic syndrome, which is known to affect blood adipokine levels. This study examined blood adipokine levels in geriatric depression after adjusting for the effects of metabolic syndrome.

Methods

Participants were selected from the Ansan Geriatric Study (depression group [n = 76] and control group [n = 76]). Blood concentrations of four adipokines (adiponectin, resistin, neutrophil-gelatinase-associated lipocalin [NGAL], and plasminogen activator inhibitor-1 [PAI-1]) were measured using immunoassays. The effects of blood adipokine concentration on the d

SUBMITTER: Lee SH 

PROVIDER: S-EPMC9889913 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature