RNA modification writers pattern in relation to tumor microenvironment and prognosis in prostate cancer.

ABSTRACT: Background: RNA modifications are important in the study of epigenetic regulatory mechanisms in immune responses and tumorigenesis. When RNA writers are mutated or disrupted in expression, the genes associated with the pathways they modify are also disrupted and can activate or repress related pathways, affecting tumorigenesis and progression. However, the potential role of RNA writers in prostate cancer is unclear. Methods: Based on data from three datasets, we describe 26 RNA writers that mediate gene expression and genetic mutation in prostate cancer and assess their expression patterns in 948 prostate cancer samples. Using principal component analysis algorithms, the RM Score was developed to quantify the RNA modification patterns of specific tumors. Results: Two d

SUBMITTER: Cheng X 

PROVIDER: S-EPMC9889935 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature