Energy metabolism disorder dictates chronic hypoxia damage in heart defect with tetralogy of fallot.

ABSTRACT:

Background

Tetralogy of Fallot (TOF) belongs to cyanotic heart damage, which is the most common in clinic. In the chronic myocardial hypoxia injury related to TOF, the potential molecular mechanism of cardiac energy metabolism remains unclear.

Materials and methods

In our study, microarray transcriptome analysis and metabonomics methods were used to explore the energy metabolism pathway during chronic hypoxia injury. The gene expression omnibus (GEO) dataset GSE132176 was obtained for analyzing the metabolic pathways. The clinical samples (right atrial tissues) of atrial septal defect (ASD) and TOF were analyzed by metabonomics. Next, we screened important pathways and important differential metabolites related to energy metabolism to explore the pathogenesis of TOF.

Resu

SUBMITTER: Liu L 

PROVIDER: S-EPMC9889939 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature