Effects of a probiotic suspension Symprove™ on a rat early-stage Parkinson's disease model.

ABSTRACT: An increasing number of studies in recent years have focused on the role that the gut may play in Parkinson's Disease (PD) pathogenesis, suggesting that the maintenance of a healthy gut may lead to potential treatments of the disease. The health of microbiota has been shown to be directly associated with parameters that play a potential role in PD including gut barrier integrity, immunity, function, metabolism and the correct functioning of the gut-brain axis. The gut microbiota (GM) may therefore be employed as valuable indicators for early diagnosis of PD and potential targets for preventing or treating PD symptoms. Preserving the gut homeostasis using probiotics may therefore lead to a promising treatment strategy due to their known benefits in improving constipation, motor impairments,

SUBMITTER: Sancandi M 

PROVIDER: S-EPMC9890174 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature