A comprehensive analysis of cytogenetics, molecular profile, and survival among pediatric acute myeloid leukemia: a prospective study from a tertiary referral center.

ABSTRACT:

Background and aims

The objectives of this study were to investigate the cyto-molecular profile and survival of pediatric acute myeloid leukemia (AML).

Methods

This prospective study was carried out in a tertiary care hospital from October 2018 to December 2020. Karyotype and cytogenetics analyses were done to identify chromosomal aberrations in pediatric AML. The targeted molecular panel utilized the polymerase chain reaction (PCR), reverse transcription-polymerase chain reaction (RT-PCR), and fragment analysis.

Results

A total of 70 patients of AML with aged ≤18 years were enrolled in this study. The cytogenetic analyses revealed abnormal/recurrent cytogenetic abnormalities (CA) in 64.3% of patients and normal cytogenetics (CN) in 35.7% of patients. FAB M2 subtype s

SUBMITTER: Meena JP 

PROVIDER: S-EPMC9890188 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature