High-throughput sequencing-based metagenomic and transcriptomic analysis of intestine in piglets infected with salmonella.

ABSTRACT: Salmonella enterica serovar Typhimurium isolate HJL777 is a virulent bacterial strain in pigs. The high rate of salmonella infection are at high risk of non-typhoidal salmonella gastroenteritis development. Salmonellosis is most common in young pigs. We investigated changes in gut microbiota and biological function in piglets infected with salmonella via analysis of rectal fecal metagenome and intestinal transcriptome using 16S rRNA and RNA sequencing. We identified a decrease in Bacteroides and increase in harmful bacteria such as Spirochaetes and Proteobacteria by microbial community analysis. We predicted that reduction of Bacteroides by salmonella infection causes proliferation of salmonella and harmful bacteria that can cause an intestinal inf

SUBMITTER: Won K 

PROVIDER: S-EPMC9890335 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature