Altered prefrontal signaling during inhibitory control in a salient drug context in cocaine use disorder.

ABSTRACT:

Introduction

Drug addiction is characterized by impaired response inhibition and salience attribution (iRISA), where the salience of drug cues is postulated to overpower that of other reinforcers with a concomitant decrease in self-control. However, the neural underpinnings of the interaction between the salience of drug cues and inhibitory control in drug addiction remain unclear.

Methods

We developed a novel stop-signal functional magnetic resonance imaging task where the stop-signal reaction time (SSRT-a classical inhibitory control measure) was tested under different salience conditions (modulated by drug, food, threat, or neutral words) in individuals with cocaine use disorder (CUD; n = 26) versus demographically matched healthy control participants (n = 26).

Results

SUBMITTER: Ceceli AO 

PROVIDER: S-EPMC9890460 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature