Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis.

ABSTRACT:

Aims

Gut microbiota and their generated metabolites impact the host vascular phenotype. The metaorganismal metabolite trimethylamine N-oxide (TMAO) is both associated with adverse clinical thromboembolic events, and enhances platelet responsiveness in subjects. The impact of TMAO on vascular Tissue Factor (TF) in vivo is unknown. Here, we explore whether TMAO-enhanced thrombosis potential extends beyond TMAO effects on platelets, and is linked to TF. We also further explore the links between gut microbiota and vascular endothelial TF expression in vivo.

Methods and results

In initial exploratory clinical studies, we observed that among sequential stable subjects (n = 2989) on anti-platelet therapy undergoing elective diagnostic cardiovascular evaluation at a single-site refe

SUBMITTER: Witkowski M 

PROVIDER: S-EPMC9890461 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature