Frailty and cardiovascular mortality in more than 3 million US Veterans.

ABSTRACT:

Aims

Frailty is associated with an increased risk of all-cause mortality and cardiovascular (CV) events. Limited data exist from the modern era of CV prevention on the relationship between frailty and CV mortality. We hypothesized that frailty is associated with an increased risk of CV mortality.

Methods and results

All US Veterans aged ≥65 years who were regular users of Veteran Affairs care from 2002 to 2017 were included. Frailty was defined using a 31-item previously validated frailty index, ranging from 0 to 1. The primary outcome was CV mortality with secondary analyses examining the relationship between frailty and CV events (myocardial infarction, stroke, revascularization). Survival analysis models were adjusted for age, sex, ethnicity, geographic region, smoking, h

SUBMITTER: Shrauner W 

PROVIDER: S-EPMC9890630 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature