Domain-specific effects of prenatal fluoride exposure on child IQ at 4, 5, and 6-12 years in the ELEMENT cohort.

ABSTRACT:

Objective

Prenatal exposure to fluoride has been associated with adverse neurodevelopmental outcomes. However, the neuropsychological profile of fluoride's developmental neurotoxicity at low levels and the stability of this relationship across childhood has not been characterized. We investigated the longitudinal and domain specific effect of prenatal fluoride exposure on IQ among children ages 4, 5, and 6-12 years in the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) cohort.

Methods

We measured the average of maternal urinary fluoride at each trimester of pregnancy adjusted for creatinine (MUF_CRE). Children were administered the McCarthy Scales of Children's Abilities at ages 4 (N = 386) and 5 (N = 308), and the Wechsler Abbreviated Scale of

SUBMITTER: Goodman CV 

PROVIDER: S-EPMC9890727 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature