Parkinson's Disease and the Gut Microbiome in Rural California.

ABSTRACT:

Background

Increasing evidence connects the gut microbiome to Parkinson's disease (PD) etiology, but little is known about microbial contributions to PD progression and its clinical features.

Objective

We aim to explore the association between the gut microbiome with PD, and the microbial association with PD-specific clinical features.

Methods

In a community-based case-control study of 96 PD patients and 74 controls, microbiome data were obtained from 16S rRNA gene sequencing of fecal samples, and analyzed for microbial diversity, taxa abundance, and predicted functional pathways that differed in PD patients and controls, and their association with PD-specific features (disease duration, motor subtypes, L-DOPA daily dose, and motor function).

Results

PD patient

SUBMITTER: Zhang K 

PROVIDER: S-EPMC9890728 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature