Hypothyroidism in hibernating brown bears.

ABSTRACT: Brown bears hibernate throughout half of the year as a survival strategy to reduce energy consumption during prolonged periods with scarcity of food and water. Thyroid hormones are the major endocrine regulators of basal metabolic rate in humans. Therefore, we aimed to determine regulations in serum thyroid hormone levels in hibernation compared to the active state to investigate if these are involved in the adaptions for hibernation.We used electrochemiluminescence immunoassay to quantify total triiodothyronine (T₃) and thyroxine (T₄) levels in hibernation and active state in paired serum samples from six subadult Scandinavian brown bears. Additionally, we determined regulations in the liver mRNA levels of three major thyroid hormone-binding proteins; thyroxine-bindi

SUBMITTER: Frobert AM 

PROVIDER: S-EPMC9890737 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature