The effect of maternal BMI, smoking and alcohol on congenital heart diseases: a Mendelian randomisation study.

ABSTRACT:

Background

Congenital heart diseases (CHDs) remain a significant cause of infant morbidity and mortality. Epidemiological studies have explored maternal risk factors for offspring CHDs, but few have used genetic epidemiology methods to improve causal inference.

Methods

Three birth cohorts, including 65,510 mother/offspring pairs (N = 562 CHD cases) were included. We used Mendelian randomisation (MR) analyses to explore the effects of genetically predicted maternal body mass index (BMI), smoking and alcohol on offspring CHDs. We generated genetic risk scores (GRS) using summary data from large-scale genome-wide association studies (GWAS) and validated the strength and relevance of the genetic instrument for exposure levels during pregnancy. Logistic regression was used to est

SUBMITTER: Taylor K 

PROVIDER: S-EPMC9890815 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature