Circulating estradiol and its biologically active metabolites in endometriosis and in relation to pain symptoms.

ABSTRACT:

Objectives

Endometriosis (EM) is an estrogen-dominant inflammatory disease linked to infertility that affects women of reproductive age. EM lesions respond to hormonal signals that regulate uterine tissue growth and trigger inflammation and pain. The objective of this study was to evaluate whether estradiol (E₂) and its biologically active metabolites are differentially associated with EM given their estrogenic and non-estrogenic actions including proliferative and inflammatory properties.

Design

We performed a retrospective study of 209 EM cases and 115 women without EM.

Methods

Pain-related outcomes were assessed using surveys with validated scales. Preoperative serum levels of estradiol (E₂) and estrone (E₁), their 2-, 4- and 16- hy

SUBMITTER: Emond JP 

PROVIDER: S-EPMC9891204 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature