Association of Social Isolation and Loneliness With Incident Heart Failure in a Population-Based Cohort Study.

ABSTRACT:

Background

Social isolation and loneliness have emerged as important risk factors for cardiovascular diseases, particularly during the coronavirus disease pandemic. However, it is unclear whether social isolation and loneliness had independent and joint associations with incident heart failure (HF).

Objectives

This study sought to examine the association of social isolation, loneliness, and their combination with incident HF.

Methods

The UK Biobank study is a population-based cohort study. Social isolation and loneliness were assessed using self-reported questionnaires. HF cases were identified by linking hospital records and death registries. The weighted polygenic risk score associated with HF was calculated.

Results

Among the 464,773 participants (mean age:

SUBMITTER: Liang YY 

PROVIDER: S-EPMC9891238 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature