N2 modified dinucleotide cap analogs as a potent tool for mRNA engineering.

ABSTRACT: mRNA-based vaccines are relatively new technologies that have been in the field of interest of research centers and pharmaceutical companies in recent years. Such therapeutics are an attractive alternative for DNA-based vaccines since they provide material that can be used with no risk of genomic integration. Additionally, mRNA can be quite easily engineered to introduce modifications for different applications or to modulate its properties, for example, to increase translational efficiency or stability, which is not available for DNA vectors. Here, we describe the use of N2 modified dinucleotide cap analogs as components of mRNA transcripts. The compounds obtained showed very promising biological properties while incorporated into mRNA. The presented N2-guanine modifications within the ca

SUBMITTER: Grzela R 

PROVIDER: S-EPMC9891257 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature