Identification of Vaccine Effects When Exposure Status Is Unknown.

ABSTRACT: Results from randomized controlled trials (RCTs) help determine vaccination strategies and related public health policies. However, defining and identifying estimands that can guide policies in infectious disease settings is difficult, even in an RCT. The effects of vaccination critically depend on characteristics of the population of interest, such as the prevalence of infection, the number of vaccinated, and social behaviors. To mitigate the dependence on such characteristics, estimands, and study designs, that require conditioning or intervening on exposure to the infectious agent have been advocated. But a fundamental problem for both RCTs and observational studies is that exposure status is often unavailable or difficult to measure, which has made it impossible to apply existing metho

SUBMITTER: Stensrud MJ 

PROVIDER: S-EPMC9891279 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature