Connectomic Basis for Tremor Control in Stereotactic Radiosurgical Thalamotomy.

ABSTRACT:

Background and purpose

Given the increased use of stereotactic radiosurgical thalamotomy and other ablative therapies for tremor, new biomarkers are needed to improve outcomes. Using resting-state fMRI and MR tractography, we hypothesized that a "connectome fingerprint" can predict tremor outcomes and potentially serve as a targeting biomarker for stereotactic radiosurgical thalamotomy.

Materials and methods

We evaluated 27 patients who underwent unilateral stereotactic radiosurgical thalamotomy for essential tremor or tremor-predominant Parkinson disease. Percentage postoperative improvement in the contralateral limb Fahn-Tolosa-Marin Clinical Tremor Rating Scale (TRS) was the primary end point. Connectome-style resting-state fMRI and MR tractography were performed before s

SUBMITTER: Middlebrooks EH 

PROVIDER: S-EPMC9891328 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature