Single-atom engineering of hemicyanine and its amphiphilic derivative for optimized near infrared phototheranostics.

ABSTRACT: Near-infrared (NIR) dyes are widely used in the field of in vivo phototheranostics. Hemicyanine dyes (HDs) have recently received tremendous attention due to their easy synthesis and excellent NIR features. However, HDs can easily form non-fluorescent aggregates and their potential for phototherapy still needs further exploration due to their poor ability to generate reactive oxygen species (ROS). Herein, a series of hemicyanine dyes with different chalcogen atom (O, S, Se) substitutions were constructed to achieve optimized potential for phototheranostics. By replacing O with the heavy atom Se in the xanthene skeleton, CySe-NEt₂ showed much more favourable features such as extended NIR absorption/emission wavelength, boosted ¹O₂ generation rate and

SUBMITTER: Yao S 

PROVIDER: S-EPMC9891367 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature