Bond breaking of furan-maleimide adducts via a diradical sequential mechanism under an external mechanical force.

ABSTRACT: Substituted furan-maleimide Diels-Alder adducts are bound by dynamic covalent bonds that make them particularly attractive mechanophores. Thermally activated [4 + 2] retro-Diels-Alder (DA) reactions predominantly proceed via a concerted mechanism in the ground electronic state. We show that an asymmetric mechanical force along the anchoring bonds in both the endo and exo isomers of proximal dimethyl furan-maleimide adducts favors a sequential pathway. The switching from a concerted to a sequential mechanism occurs at external forces of ≈1 nN. The first bond rupture occurs for a projection of the pulling force on the scissile bond at ≈4.3 nN for the exo adduct and ≈3.8 nN for the endo one. The reaction is inhibited for external forces up to ≈3.4 nN for the

SUBMITTER: Cardosa-Gutierrez M 

PROVIDER: S-EPMC9891376 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature