Chelating chloride using binuclear lanthanide complexes in water.

ABSTRACT: Halide recognition by supramolecular receptors and coordination complexes in water is a long-standing challenge. In this work, we report chloride binding in water and in competing media by pre-organised binuclear kinetically inert lanthanide complexes, bridged by flexible -(CH₂)₂- and -(CH₂)₃- spacers, forming [Ln₂(DO3A)₂C-2] and [Ln₂(DO3A)₂C-3], respectively. These hydrophilic, neutral lanthanide coordination complexes are shown to bind chloride with apparent association constants of up to 10⁵ M^-1 in water and in buffered systems. Hydroxide bridging was observed in these complexes at basic pH, which was proven to be overcome by chloride. Thus, these lanthanide complexes show promi

SUBMITTER: Alexander C 

PROVIDER: S-EPMC9891377 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature