Interstitial lung disease in ANCA-associated vasculitis: associated factors, radiographic features and mortality.

ABSTRACT:

Objective

To evaluate the prevalence, clinical and radiographic features, and long-term outcomes of interstitial lung disease (ILD) in a United States-based ANCA-associated vasculitis (AAV) cohort.

Methods

In this retrospective cohort study, we identified cases of ILD within the 2002-2019 Mass General Brigham AAV Cohort, a consecutive inception cohort of PR3- or MPO-ANCA+ AAV patients. ILD diagnosis and classification as fibrotic or non-fibrotic were confirmed by review of available chest imaging by two board-certified radiologists. Cox proportional hazard models, with age as the time scale, were used to estimate the association of AAV-ILD with all-cause mortality.

Results

Of 684 patients in the MGB AAV Cohort, 91 (13%) had ILD which preceded the diagnosis of AAV by a

SUBMITTER: Doliner B 

PROVIDER: S-EPMC9891428 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature