Resting state functional connectivity in SLE patients and association with cognitive impairment and blood-brain barrier permeability.

ABSTRACT:

Objective

Extensive blood-brain barrier (BBB) leakage has been linked to cognitive impairment in SLE. This study aimed to examine the associations of brain functional connectivity (FC) with cognitive impairment and BBB dysfunction among patients with SLE.

Methods

Cognitive function was assessed by neuropsychological testing (n = 77). Resting-state FC (rsFC) between brain regions, measured by functional MRI (n = 78), assessed coordinated neural activation in 131 regions across five canonical brain networks. BBB permeability was measured by dynamic contrast-enhanced MRI (n = 61). Differences in rsFC were compared between SLE patients with cognitive impairment (SLE-CI) and those with normal cognition (SLE-NC), between SLE patients with and without extensive BBB leakage, and wit

SUBMITTER: Hanly JG 

PROVIDER: S-EPMC9891437 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature