Decoupling of interacting neuronal populations by time-shifted stimulation through spike-timing-dependent plasticity.

ABSTRACT: The synaptic organization of the brain is constantly modified by activity-dependent synaptic plasticity. In several neurological disorders, abnormal neuronal activity and pathological synaptic connectivity may significantly impair normal brain function. Reorganization of neuronal circuits by therapeutic stimulation has the potential to restore normal brain dynamics. Increasing evidence suggests that the temporal stimulation pattern crucially determines the long-lasting therapeutic effects of stimulation. Here, we tested whether a specific pattern of brain stimulation can enable the suppression of pathologically strong inter-population synaptic connectivity through spike-timing-dependent plasticity (STDP). More specifically, we tested how introducing a time shift between stimuli delivered t

SUBMITTER: Madadi Asl M 

PROVIDER: S-EPMC9891531 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature